Efficacy Of ICSI Technology

The objective behind developing micromanipulation techniques was to deliver the
sperm into the egg to solve the problem of infertility in male. ICSI technology i.e.
intracytoplasmic sperm injection) is also among these techniques. However, it is
more advanced. The process of ICSI needs merely one viable sperm instead of
using number of good quality sperm like in IVF, GIFT and ZIFT. This sperm may
not be highly motile or have some specific structures for the normal penetration
into the egg. The only requirement for sperm in ICSI process is that it must be
viable and have normal morphology.

ICSI is a process, in which a specially developed single sperm is injected into a
mature egg with the help of a high-powered microscope. This process is used to
effect fertilization.

The cumulus and coronal layers are removed from the egg by the embryologist.
The sperm is prepared by washing them in a special kind of solution. Thereafter,
search for the most motile and viable sperm is done by using high-powered
magnification. On finding a viable sperm, it is injected into the stabilized and
prepared egg after the sperm is drawn up into a very fine needle with the help of
high magnification.

The usefulness of ICSI technology is very clear from the fact that only single
sperm is required. Thus, it may prove really helpful for men with low sperm count.
Since, to form one embryo, one good sperm and one good egg are needed.
Another idea but less obvious is that viable sperm can be found in other parts of
the reproductive tract of male having low or absent sperm count. Thus, their
chances of becoming father increases as ICSI can use sperm even from different
parts of the male reproductive tract. The only condition is that the sperm must be
alive. It is not necessarily be motile, since this process is not dependent on
motility to get sperm to egg and via the egg’s zona pellucida (outer covering).

Testicular biopsy and ICSI may also prove beneficial for those men who produce
live sperm but these sperm disposed of in the body. Besides this, even if an
otherwise viable sperm is produced, then these sperm are not able to penetrate
an egg. Thus, technology is helpful to even for these men.

ICSI technology has also been used in various other spheres where the objective
is to maximize fertilizations ranging from inexplicable infertility to save the eggs,
which have been harvested but failed to fertilize. It has also been reported that
ICSI may prove helpful in cases where quality of egg is reduced or even
questionable in some cases.

Lately researches are being done to extend the benefits of ICSI by making it
useful for men who cannot produce sperm and have zero sperm. Thus, overall it
can be concluded that ICSI process may be counted as a promising technology
for men to biologically fathering a child.




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